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Because clonazepam undergoes hepatic metabolism, it is possible that liver disease will impair clonazepam elimination.Thus, caution should be exercised when administering clonazepam to these patients.
Clonazepam is rapidly and completely absorbed after oral administration.
The absolute bioavailability of clonazepam is about 90%.
A taming effect in aggressive primates, muscle weakness and hypnosis are also produced.
In humans, clonazepam is capable of suppressing the spike and wave discharge in absence seizures (petit mal) and decreasing the frequency, amplitude, duration and spread of discharge in minor motor seizures.
Chemically, clonazepam is 5-(2-chlorophenyl)-1,3-dihydro-7-nitro-2 The precise mechanism by which clonazepam exerts its anti-seizure and anti-panic effects is unknown, although it is believed to be related to its ability to enhance the activity of gamma aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system.